p(HGNC:MAPT, frag("1_368")) increases path(HBP:Neurodegeneration)

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PubMed:26631930

The truncation of tau at Asn368 has been observed in human AD brains and in a P301S mouse model of tauopathy, in which it leads to the generation of a tau1–368 fragment that is prone to aggregation and shows compromised microtubule-assembly activity, possibly contributing to tau aggregation and neurodegeneration.

Related Edges 2

• p(HGNC:MAPT, frag("1_368")) increases a(HBP:"Tau aggregates")
• p(HGNC:MAPT, frag("1_368")) decreases bp(GO:"microtubule polymerization")

MeSH

Brain

MeSH

Alzheimer Disease

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