p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta")

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PubMed:18986241

It is also important to note that TrkA reduces and p75NTR activates β-secretase strike (BACE) cleavage of the amyloid precursor protein (APP), which requires NGF binding and activation of the second messenger ceramide [66]. Aging may activate beta-amyloid (Ab) generation in the brain by ‘switching’ from TrkA to p75NTR, suggesting that NGF receptor balance is a molecular link between normal aging of the brain and AD in relation to amyloid processing.

Related Edges 4

• bp(MESH:D000375) increases p(HGNC:NGFR)
• p(HGNC:NTRK1) decreases act(p(HGNC:BACE1))
• p(HGNC:NGFR) increases act(p(HGNC:BACE1))
• act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta")

Disease Ontology (DO)

Alzheimer's disease

MeSH

Cognitive Dysfunction

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