act(p(HGNC:BACE1)) increases a(CHEBI:"amyloid-beta")

View Subject View Object

PubMed:18986241

It is also important to note that TrkA reduces and p75NTR activates β-secretase strike (BACE) cleavage of the amyloid precursor protein (APP), which requires NGF binding and activation of the second messenger ceramide [66]. Aging may activate beta-amyloid (Ab) generation in the brain by ‘switching’ from TrkA to p75NTR, suggesting that NGF receptor balance is a molecular link between normal aging of the brain and AD in relation to amyloid processing.

Related Edges 4

• bp(MESH:D000375) increases p(HGNC:NGFR)
• p(HGNC:NTRK1) decreases act(p(HGNC:BACE1))
• p(HGNC:NGFR) increases act(p(HGNC:BACE1))
• p(HGNC:NGFR) increases a(CHEBI:"amyloid-beta")

Disease Ontology (DO)

Alzheimer's disease

MeSH

Cognitive Dysfunction

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---