p(HGNC:PPP2CA, pmod(Me)) increases act(p(HGNC:PPP2CA))

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PubMed:29228318

These findings suggest a scenario in which MC-LR-mediated demethylation of PP2Ac is associated with GSK-3β phosphorylation at Ser9 and contributes to dissociation of Bα from PP2Ac, which would result in Bα degradation and disruption of PP2A/Bα-tau interactions, thus promoting tau hyperphosphorylation and paired helical filaments-tau accumulation and, consequently, axonal degeneration and cell death.

Related Edges 2

• a(CHEBI:"microcystin-LR") decreases p(HGNC:PPP2CA, pmod(Me))
• act(p(HGNC:PPP2CA)) directlyDecreases p(HGNC:GSK3B, pmod(Ph, Ser, 9))

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