Title

Microcystin-Leucine-Arginine Induces Tau Pathology Through Bα Degradation via Protein Phosphatase 2A Demethylation and Associated Glycogen Synthase Kinase-3β Phosphorylation.

Journal

Toxicological sciences : an official journal of the Society of Toxicology

Volume

162

Issue

None

Pages

475-487

Date

2018-04-01

Authors

Fan Y | Feng Y | Li Y | Qian W | Wang E | Wang Y | Yin H | Yuan T | Zhang J | Zhang Y

These findings suggest a scenario in which MC-LR-mediated demethylation of PP2Ac is associated with GSK-3β phosphorylation at Ser9 and contributes to dissociation of Bα from PP2Ac, which would result in Bα degradation and disruption of PP2A/Bα-tau interactions, thus promoting tau hyperphosphorylation and paired helical filaments-tau accumulation and, consequently, axonal degeneration and cell death.

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