a(CHEBI:"okadaic acid") decreases act(p(FPLX:PPP2))

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PubMed:22299660

Similar findings have been observed in metabolically active rat brain slices, where a selective inhibition of PP2A with OA results in an aberrant phosphorylation of tau at the same residues seen in AD brains at serines (Ser) 198, 199, 202, 396, 404, 422 and 262 [11, 47, 48].

Related Edges 21

• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 189))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 199))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 202))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 396))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 404))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 422))
• a(CHEBI:"okadaic acid") increases p(HGNC:MAPT, pmod(Ph, Ser, 262))
• p(HGNC:MAPT, pmod(Ph, Ser, 189)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 199)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 262)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 396)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 404)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(Ph, Ser, 422)) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 189))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 199))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 396))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 404))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 422))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 262))

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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