act(p(HGNC:CHRNA7)) increases bp(GO:cognition)

PubMed:19721446

First, there is a high level of expression of alpha7 nAChRs in the hippocampus, a region that is known to be involved in memory formation. Second, gene knockout and antisense studies have shown a role for alpha7 nAChRs in learning and memory144–146, and specifically in attention and working–episodic memory147,148. Third, pharmacological studies have shown that a range of structurally diverse alpha7 nAChR-selective agonists or positive allosteric modulators improve the cognitive deficits that are associated with Alzheimer’s disease.

Related Edges 8

• a(MESH:Hippocampus) association p(HGNC:CHRNA7)
• a(MESH:Hippocampus) association bp(GO:memory)
• bp(GO:learning) association p(HGNC:CHRNA7)
• bp(GO:memory) association a(MESH:Hippocampus)
• bp(GO:memory) association p(HGNC:CHRNA7)
• p(HGNC:CHRNA7) association a(MESH:Hippocampus)
• p(HGNC:CHRNA7) association bp(GO:memory)
• p(HGNC:CHRNA7) association bp(GO:learning)

MeSH

Alzheimer Disease

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.