a(MESH:Hippocampus) association p(HGNC:CHRNA7)

PubMed:19721446

First, there is a high level of expression of alpha7 nAChRs in the hippocampus, a region that is known to be involved in memory formation. Second, gene knockout and antisense studies have shown a role for alpha7 nAChRs in learning and memory144–146, and specifically in attention and working–episodic memory147,148. Third, pharmacological studies have shown that a range of structurally diverse alpha7 nAChR-selective agonists or positive allosteric modulators improve the cognitive deficits that are associated with Alzheimer’s disease.

Related Edges 8

• a(MESH:Hippocampus) association bp(GO:memory)
• bp(GO:learning) association p(HGNC:CHRNA7)
• bp(GO:memory) association a(MESH:Hippocampus)
• bp(GO:memory) association p(HGNC:CHRNA7)
• act(p(HGNC:CHRNA7)) increases bp(GO:cognition)
• p(HGNC:CHRNA7) association a(MESH:Hippocampus)
• p(HGNC:CHRNA7) association bp(GO:memory)
• p(HGNC:CHRNA7) association bp(GO:learning)

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