p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation bp(GO:"neurofibrillary tangle assembly")

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PubMed:17050703

Tau-nY29 detects soluble tau and paired helical filament tau from severely affected Alzheimer's brain but fails to recognize tau from normal aged brain. This observation suggests that nitration at Tyr29 is a disease-related event that may alter the intrinsic ability of tau to self-polymerize. In Alzheimer's brain, Tau-nY29 labels the fibrillar triad of tau lesions, including neurofibrillary tangles, neuritic plaques, and, to a lesser extent, neuropil threads. Intriguingly, although Tau-nY29 stains both the neuronal and glial tau pathology of Pick disease, it detects only the neuronal pathology in corticobasal degeneration and progressive supranuclear palsy without labeling the predominant glial pathology.

Related Edges 7

• bp(GO:"neurofibrillary tangle assembly") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) positiveCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(HBP:"Corticobasal Degeneration")
• p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29)) association path(MESH:"Supranuclear Palsy, Progressive")
• path(HBP:"Corticobasal Degeneration") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
• path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))
• path(MESH:"Supranuclear Palsy, Progressive") association p(HGNC:MAPT, pmod(HBP:nitration, Tyr, 29))

Disease Ontology (DO)

Alzheimer's disease

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