p(HGNC:GSK3B) association p(HGNC:YWHAZ)

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PubMed:12551948

These observations suggested that 14-3-3zeta may be bound to GSK3Beta and/or tau within brain microtubules and may be a component of tau phosphorylation complex.Therefore, 14-3-3 must be the central molecule that holds tau and GSK3Beta within the complex. Indeed, FLAG-tau co-immunoprecipitated with HA-GSK3Beta from cells overexpressing FLAG-tau and HA-GSK3Beta only when these cells also overexpressed Xpress-14-3-3zeta (Fig. 6A, lanes 8 and 9), indicating that GSK3Beta associates with tau only in the presence of 14-3-3zeta. As discussed above, 14-3-3zeta binds to tau (36) and GSK3Beta (Fig. 5) directly. Taken together, these observations indicated that 14-3-3zeta connects GSK3Beta to tau in vivo.

Related Edges 3

• p(HGNC:MAPT) association p(HGNC:YWHAZ)
• p(HGNC:YWHAZ) association p(HGNC:MAPT)
• p(HGNC:YWHAZ) association p(HGNC:GSK3B)

Experimental Factor Ontology (EFO)

HEK293

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