p(HGNC:APP, pmod(Sumo)) increases a(CHEBI:"amyloid-beta")

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PubMed:12506199

Increased protein sumoylation resulting from overexpression of SUMO-3 reduces Abeta production and reducing endogenous protein sumoylation with dominant-negative SUMO-3 mutants increases Abeta production. Mutant SUMO-3, K11R, which can only be monomerically conjugated to target proteins, has an opposite effect on Abeta generation to that by SUMO-3, which can form polymeric chains on target proteins. Polysumoylation reduces whereas monosumoylation or undersumoylation enhances Abeta generation.

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• p(HGNC:APP, pmod(HBP:polysumoylation)) decreases a(CHEBI:"amyloid-beta")

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