Title

Positive and negative regulation of APP amyloidogenesis by sumoylation.

Journal

Proceedings of the National Academy of Sciences of the United States of America

Volume

100

Issue

None

Pages

259-64

Date

2003-01-07

Authors

Cordell B | Li Y | Liu YW | Quon D | Wang H | Wang S

Increased protein sumoylation resulting from overexpression of SUMO-3 reduces Abeta production and reducing endogenous protein sumoylation with dominant-negative SUMO-3 mutants increases Abeta production. Mutant SUMO-3, K11R, which can only be monomerically conjugated to target proteins, has an opposite effect on Abeta generation to that by SUMO-3, which can form polymeric chains on target proteins. Polysumoylation reduces whereas monosumoylation or undersumoylation enhances Abeta generation.

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