act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization")

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PubMed:22941973

When overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in Ser(262) phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. Downregulation of synaptophysin in 14-3-3z overexpressing neurons was mitigated by inhibiting the proteosome, indicating that 14-3-3z promotes proteosomal degradation of synaptophysin. When 14-3-3z overexpressing neurons were treated with the microtubule stabilizing drug taxol, tau Ser(262) phosphorylation decreased and synaptophysin level was restored.

Related Edges 5

• a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain"))
• a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262))
• act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262))
• act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp))
• act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel)

Uberon

hippocampal formation

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