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PubMed: 22941973

Title
Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain.
Journal
Journal of Alzheimer's disease : JAD
Volume
33
Issue
None
Pages
249-63
Date
2013-01-01
Authors
DeTure M | Dickson DW | Ebrahim AS | Kang D | Knight J | Lewis J | Pedersen JT | Ren Y | Sahara N | Volbracht C | Yen SH

Evidence f34275c663
JSON

When overexpressed in rat hippocampal primary neurons, 14-3-3z causes an increase in Ser(262) phosphorylation, a decrease in the amount of microtubule-bound tau, a reduction in the amount of polymerized microtubules, as well as microtubule instability. Downregulation of synaptophysin in 14-3-3z overexpressing neurons was mitigated by inhibiting the proteosome, indicating that 14-3-3z promotes proteosomal degradation of synaptophysin. When 14-3-3z overexpressing neurons were treated with the microtubule stabilizing drug taxol, tau Ser(262) phosphorylation decreased and synaptophysin level was restored.

a(CHEBI:paclitaxel) negativeCorrelation act(p(INTERPRO:"14-3-3 domain")) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

a(CHEBI:paclitaxel) decreases p(RGD:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(INTERPRO:"14-3-3 domain")) increases p(RGD:Mapt, pmod(Ph, Ser, 262)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(INTERPRO:"14-3-3 domain")) decreases bp(GO:"microtubule polymerization") View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(INTERPRO:"14-3-3 domain")) increases deg(p(RGD:Syp)) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

act(p(INTERPRO:"14-3-3 domain")) negativeCorrelation a(CHEBI:paclitaxel) View Subject | View Object

Appears in Networks:
Annotations
Uberon
hippocampal formation

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