p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk)

View Subject View Object

PubMed:25331948

We further validated Syk as a target-regulating Aβ by showing that pharmacological inhibition of Syk or down-regulation of Syk expression reduces Aβ production and increases the clearance of Aβ across the BBB mimicking (-)-nilvadipine effects. Moreover, treatment of transgenic mice overexpressing Aβ and transgenic Tau P301S mice with a selective Syk inhibitor respectively decreased brain Aβ accumulation and Tau hyperphosphorylation at multiple AD relevant epitopes.

Related Edges 10

• a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Syk)
• act(p(HGNC:GSK3B), ma(kin)) increases a(HBP:"Tau epitope, PHF1")
• p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk)
• p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk)
• p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk)
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18))
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396))
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 404))
• p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta")
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202))

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---