p(MGI:Syk) positiveCorrelation a(CHEBI:"amyloid-beta")

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PubMed:25331948

We further validated Syk as a target-regulating Aβ by showing that pharmacological inhibition of Syk or down-regulation of Syk expression reduces Aβ production and increases the clearance of Aβ across the BBB mimicking (-)-nilvadipine effects. Moreover, treatment of transgenic mice overexpressing Aβ and transgenic Tau P301S mice with a selective Syk inhibitor respectively decreased brain Aβ accumulation and Tau hyperphosphorylation at multiple AD relevant epitopes.

Related Edges 10

• a(CHEBI:"amyloid-beta") positiveCorrelation p(MGI:Syk)
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• p(MGI:Mapt, pmod(Ph, Ser, 202)) positiveCorrelation p(MGI:Syk)
• p(MGI:Mapt, pmod(Ph, Ser, 396)) positiveCorrelation p(MGI:Syk)
• p(MGI:Mapt, pmod(Ph, Ser, 404)) positiveCorrelation p(MGI:Syk)
• p(MGI:Mapt, pmod(Ph, Tyr, 18)) positiveCorrelation p(MGI:Syk)
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Tyr, 18))
• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 396))
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• p(MGI:Syk) positiveCorrelation p(MGI:Mapt, pmod(Ph, Ser, 202))

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