p(HGNC:CCT5) causesNoChange a(HBP:"huntingtin aggregates")

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PubMed:25437566

These included all subunits of the CCT/TRiC complex (except CCT5); HSP40 and HSP70 family members DNAJA1 (HDJ-2), DNAJA4, HSPA8 (HSC70), and HSPA14 (Figures 5B and 5C); and the TPR-domain APC/C subunits CDC23 and CDC27 that, upon knockdown, led to significantly elevated aggregation (Figure S5B).

Related Edges 7

• p(FPLX:"CCT_complex") increases a(HBP:"huntingtin aggregates")
• p(HGNC:CDC23) increases a(HBP:"huntingtin aggregates")
• p(HGNC:CDC27) increases a(HBP:"huntingtin aggregates")
• p(HGNC:DNAJA1) increases a(HBP:"huntingtin aggregates")
• p(HGNC:DNAJA4) increases a(HBP:"huntingtin aggregates")
• p(HGNC:HSPA14) increases a(HBP:"huntingtin aggregates")
• p(HGNC:HSPA8) increases a(HBP:"huntingtin aggregates")

MeSH

Brain

MeSH

Alzheimer Disease

MeSH

Huntington Disease

MeSH

Parkinson Disease

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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