complex(FPLX:"Gamma_secretase") increases rxn(reactants(a(HBP:HBP00081)), products(a(HBP:HBP00071), a(MESH:"Amyloid beta-Peptides")))

View Subject View Object

PubMed:22122372

gamma-Secretase further cleaves C99 to release AICD and the amyloidogenic Abeta peptide which aggregates and fibrillates to form amyloid plaques in the brain

Related Edges 4

• a(CHEBI:"amyloid-beta") increases a(HBP:HBP00038)
• a(CHEBI:"amyloid-beta") increases a(HBP:HBP00018)
• a(HBP:HBP00018) increases path(MESH:"Plaque, Amyloid")
• a(HBP:HBP00038) increases path(MESH:"Plaque, Amyloid")

Confidence

Medium

MeSH

Neurons

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---