a(CHEBI:nicotine) association bp(GO:"negative regulation of apoptotic process")

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PubMed:19293145

Hepatic vagus nerve activity has recently been shown to protect hepatocytes from Fas-induced apoptosis via activation of alpha7 nAChRs (Hiramoto et al., 2008). Thus, nicotine seems to exert a general pro-survival action not only on neurons but also on non-neuronal cells, suggesting that the protection offered by nicotine against Abeta toxicity may therefore simply be the result of a general pro-survival response.

Related Edges 4

• act(a(MESH:"Vagus Nerve")) increases act(p(HGNC:CHRNA7))
• bp(GO:"negative regulation of apoptotic process") association a(CHEBI:nicotine)
• act(p(HGNC:CHRNA7)) decreases act(p(HGNC:FAS))
• act(p(HGNC:FAS)) increases bp(GO:"programmed cell death")

MeSH

Liver

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