a(GO:"neurofibrillary tangle") association p(HGNC:BECN1, frag("?"))

View Subject View Object

PubMed:29758300

For example, levels of Beclin 1, a key component of the class III type phosphoinositide 3-kinase/VPS34 complex essential to the pre-autophagosomal structure (PAS), has been suggested to be reduced in AD brains [16,17], with Rohn et al. demonstrating the cleavage of Beclin 1 by caspase-3 in the AD brain and colocalization of the cleaved product with NFTs [16].

Related Edges 4

• p(HGNC:BECN1) negativeCorrelation path(MESH:"Alzheimer Disease")
• p(HGNC:BECN1, frag("?")) association a(GO:"neurofibrillary tangle")
• p(HGNC:CASP3) increases p(HGNC:BECN1, frag("?"))
• path(MESH:"Alzheimer Disease") negativeCorrelation p(HGNC:BECN1)

MeSH

Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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