p(HGNC:PPP2CA, pmod(Me, Leu, 309)) increases act(p(FPLX:PPP2))

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PubMed:23943618

Notably, methylation of PP2A catalytic C subunit on the Leu- 309 residue by leucine carboxyl methyltransferase 1 (LCMT1) promotes the biogenesis and stabilization of PP2A/B
enzymes (20). We have shown that decreased LCMT1 activity and/or expression levels correlate with down-regulation of PP2A methylation and PP2A/B
expression levels and with concomitant accumulation of phospho-Tau in AD-affected brain regions (21), in cultured N2a neuroblastoma cells and in vivo

Related Edges 5

• complex(p(FPLX:PPP2), p(HGNC:MAPT)) positiveCorrelation act(p(FPLX:PPP2))
• complex(p(FPLX:PPP2), p(HGNC:MAPT)) negativeCorrelation p(HGNC:MAPT, pmod(Ph))
• act(p(FPLX:PPP2)) positiveCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(Ph)) negativeCorrelation complex(p(FPLX:PPP2), p(HGNC:MAPT))
• p(HGNC:LCMT1) increases p(HGNC:PPP2CA, pmod(Me, Leu, 309))

Disease Ontology (DO)

Alzheimer's disease

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