complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99))

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PubMed:24590577

Abeta, an important player in AD, is derived from beta-amyloid precursor protein (APP) through sequential cleavages by beta- and gamma-secretases: APP is cleaved by beta-secretase (BACE1) to generate the large secreted derivative sAPPbeta and the membrane-bound APP C-terminal fragment-beta; the latter can be further cleaved by gamma-secretase to generate Abeta and APP intracellular domain. Alternatively, APP can be cleaved by alpha-secretase within the Abeta domain, which precludes Abeta production and instead generates secreted sAPPalpha that has been shown to be neuroprotective

Related Edges 8

• a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection)
• complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta")
• complex(FPLX:"Gamma_secretase") increases a(HBP:AICD)
• p(HGNC:BACE1) increases deg(p(HGNC:APP))
• p(HGNC:BACE1) increases a(HBP:"sAPP-beta")
• p(HGNC:BACE1) increases a(HBP:C99)
• p(HGNC:ADAM10) increases deg(p(HGNC:APP))
• p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha")

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