p(HGNC:ADAM10) increases deg(p(HGNC:APP))

View Subject View Object

PubMed:24590577

Abeta, an important player in AD, is derived from beta-amyloid precursor protein (APP) through sequential cleavages by beta- and gamma-secretases: APP is cleaved by beta-secretase (BACE1) to generate the large secreted derivative sAPPbeta and the membrane-bound APP C-terminal fragment-beta; the latter can be further cleaved by gamma-secretase to generate Abeta and APP intracellular domain. Alternatively, APP can be cleaved by alpha-secretase within the Abeta domain, which precludes Abeta production and instead generates secreted sAPPalpha that has been shown to be neuroprotective

Related Edges 8

• a(HBP:"sAPP-alpha") increases bp(MESH:Neuroprotection)
• complex(FPLX:"Gamma_secretase") increases deg(a(HBP:C99))
• complex(FPLX:"Gamma_secretase") increases a(CHEBI:"amyloid-beta")
• complex(FPLX:"Gamma_secretase") increases a(HBP:AICD)
• p(HGNC:BACE1) increases deg(p(HGNC:APP))
• p(HGNC:BACE1) increases a(HBP:"sAPP-beta")
• p(HGNC:BACE1) increases a(HBP:C99)
• p(HGNC:ADAM10) increases a(HBP:"sAPP-alpha")

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---