bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))

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PubMed:8226987

>8 phosphates per tau molecules (vs 2 in adult healthy brain); can also be increased during development, hibernation and temperature, heat and oxydative stress These phosphorylated states are detected by specific antibodies and are targets of proline-directed kinases (SP motifs), non-proline kinases (KXGS motif) Weakens tau-MT interaction especially S261 in R1 and S214 in proline-rich domain

Related Edges 3

• bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))
• p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT))
• p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT))

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