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PubMed: 8226987

Title
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease.
Journal
The Journal of biological chemistry
Volume
268
Issue
None
Pages
24374-84
Date
1993-11-15
Authors
Alonso AC | Grundke-Iqbal I | Iqbal K | Köpke E | Shaikh S | Tung YC

Evidence edcc8e4d68
JSON

>8 phosphates per tau molecules (vs 2 in adult healthy brain); can also be increased during development, hibernation and temperature, heat and oxydative stress These phosphorylated states are detected by specific antibodies and are targets of proline-directed kinases (SP motifs), non-proline kinases (KXGS motif) Weakens tau-MT interaction especially S261 in R1 and S214 in proline-rich domain

bp(MESH:"Hot Temperature") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Appears in Networks:

bp(MESH:"Oxidative Stress") increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 214)) decreases act(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 261)) decreases act(p(HGNC:MAPT)) View Subject | View Object

Appears in Networks:

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