p(HGNC:GSK3B) increases p(HGNC:MAPT, pmod(HBP:hyperphosphorylation))

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PubMed:12428809

Neuronally overexpressed GSK-3β was demonstrated to hyperphosphorylate tau protein in vivo in the brain and spinal cord of double- transgenic mice (Spittaels et al., 2000) thereby reducing the amount of protein tau associated with microtubules by 50% (Spittaels et al., 2000).

Related Edges 1

• p(HGNC:GSK3B) decreases complex(a(MESH:Microtubules), p(HGNC:MAPT))

MeSH

Brain

MeSH

Spinal Cord

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