p(HGNC:MAPT) decreases bp(GO:autophagy)

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PubMed:26751493

An additional “knot” of tau being entangled in epigenetic landscape of neurodegeneration comes from the finding that by acting as a HDAC6 inhibitor, tau is being indirectly involved in both (dys)regulation of transcriptional activity and impairment of autophagic clearance by the ubiquitin proteasome system [81,82].

Related Edges 3

• act(complex(GO:"proteasome complex")) negativeCorrelation p(HGNC:MAPT)
• p(HGNC:MAPT) decreases act(p(HGNC:HDAC6))
• p(HGNC:MAPT) negativeCorrelation act(complex(GO:"proteasome complex"))

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