complex(a(MESH:"HSP70 Heat-Shock Proteins"), g(NCBIGENE:406950)) regulates act(a(MESH:"HSP70 Heat-Shock Proteins"))

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PubMed:30663117

By linking to the 3′‐UTR sequence of Hsp70 mRNA, miR‐16‐1 configures Hsp70. Its increase reduces the Hsp70, which in turn boosts the aggregation of α‐synuclein protein, and this increases the incidence of PD.

Related Edges 4

• a(HBP:"alpha-synuclein aggregates") increases path(MESH:"Parkinson Disease")
• a(MESH:"HSP70 Heat-Shock Proteins") decreases a(HBP:"alpha-synuclein aggregates")
• a(MESH:"HSP70 Heat-Shock Proteins") negativeCorrelation g(NCBIGENE:406950)
• g(NCBIGENE:406950) negativeCorrelation a(MESH:"HSP70 Heat-Shock Proteins")

MeSH

Parkinson Disease

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