p(HGNC:BACE1) increases a(CHEBI:"amyloid-beta")

PubMed:22122372

Knocking out the BACE1 gene prevents Abeta generation and completely abolishes Abeta pathology in mice expressing the Swedish mutation of human APP (Cai et al. 2001; Luo et al. 2001; Roberds et al. 2001; Ohno et al. 2004; Laird et al. 2005)

Confidence

High

MeSH

Neurons

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