path(MESH:D000544) decreases complex(a(CHEBI:"magnesium(2+)"), p(GFAM:"Glutamate ionotropic receptor NMDA type subunits"))

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PubMed:16273023

In Alzheimer's disease, however, it is believed that Mg2+ is displaced from the NMDA receptor calcium channel even under resting conditions, due to the elevated levels of glutamate that are present in the synapse at all times.13 It has been hypothesized that this constant activation of NMDA receptors leads to neuronal overactivity while also contributing to an unfavorable signal-to-noise ratio during glutamatergic neurotransmission and, hence, to the absence of LTP.

Related Edges 1

• act(p(GFAM:"Glutamate ionotropic receptor NMDA type subunits")) decreases bp(MESH:D017774)

Disease Ontology (DO)

Alzheimer's disease

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