path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurofibrillary Tangles")

PubMed:19126755

AD is the most common form of dementia in the elderly population. The histopathology of this disease is well known to have at least four components: 1) loss of cholinergic neurotransmission, 2) deposition of extracellular Abeta peptides into plaques, 3) hyperphosphorylation of the tau protein that leads to excessive formation of neurofibrillar tangles, and 4) increased local inflammation.

Related Edges 9

• bp(GO:"synaptic transmission, cholinergic") negativeCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:Dementia)
• path(MESH:"Alzheimer Disease") negativeCorrelation bp(GO:"synaptic transmission, cholinergic")
• path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Plaque, Amyloid")
• path(MESH:"Alzheimer Disease") positiveCorrelation path(MESH:"Neurogenic Inflammation")
• path(MESH:"Neurofibrillary Tangles") positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Neurogenic Inflammation") positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Plaque, Amyloid") positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:Dementia) positiveCorrelation path(MESH:"Alzheimer Disease")

Text Location

Review

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.