act(p(HGNC:CASP3)) positiveCorrelation path(MESH:"Alzheimer Disease")

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PubMed:24027553

In order for caspase to cleave tau in the AD brain, it needs to be present in its active form. The active forms of both caspase-3 and caspase-6 are elevated in AD-specific brain regions (temporal and frontal lobes) compared to unaffected regions (cerebellum) and control brains (57, 58).

Related Edges 3

• act(p(HGNC:CASP6)) positiveCorrelation path(MESH:"Alzheimer Disease")
• path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP3))
• path(MESH:"Alzheimer Disease") positiveCorrelation act(p(HGNC:CASP6))

MeSH

Frontal Lobe

MeSH

Temporal Lobe

Text Location

Review

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