act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Alzheimer Disease")

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PubMed:23531502

We were prompted to carry out this study because Acr is mainly localized in the neurons [54], is found in association with NFTs and dystrophic neurites surrounding senile plaques [55], is highly toxic to neurons, is found elevated 2–5 fold in affected regions of AD brain. EC can sequester highly reactive and toxic byproducts of oxidation such as acrolein.

Related Edges 8

• a(CHEBI:"(-)-epicatechin") increases complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein))
• act(a(CHEBI:acrolein)) positiveCorrelation a(GO:"neurofibrillary tangle")
• act(a(CHEBI:acrolein)) positiveCorrelation path(MESH:"Plaque, Amyloid")
• act(a(CHEBI:acrolein)) decreases a(MESH:Neurons)
• a(GO:"neurofibrillary tangle") positiveCorrelation act(a(CHEBI:acrolein))
• complex(a(CHEBI:"(-)-epicatechin"), a(CHEBI:acrolein)) decreases act(a(CHEBI:acrolein))
• path(MESH:"Alzheimer Disease") positiveCorrelation act(a(CHEBI:acrolein))
• path(MESH:"Plaque, Amyloid") positiveCorrelation act(a(CHEBI:acrolein))

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