a(CHEBI:"NMDA receptor antagonist") decreases act(a(MESH:D009474))

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PubMed:16273023

With regard to the glutamatergic system, studies suggest that ChEIs may stimulate the release of glutamate from pyramidal neurons during normal neuronal activity, while NMDA receptor antagonists are believed to block the abnormal neuronal activity that results from the presence of excess glutamate in the synapse under resting conditions. Thus, ChEIs and NMDA receptor antagonists appear to have complementary effects, as the former enhance the signals received by postsynaptic neurons during normal neurotransmission, and the latter diminish the background 'noise' that is constantly being detected by those same receptors.

Related Edges 1

• a(MESH:D002800) increases bp(GO:"GO:0014047")

Cell Ontology (CL)

pyramidal neuron

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