path(MESH:"Alzheimer Disease") increases act(p(HGNC:TGM2))

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PubMed:9099822

Total transglutaminase activity was significantly higher in the Alzheimer's disease prefrontal cortex compared to control. In addition the levels of tissue transglutaminase, as determined by quantitative immunoblotting, were elevated approximately 3-fold in Alzheimer's disease prefrontal cortex compared to control. To our knowledge, this is the first demonstration that transglutaminase is increased in Alzheimer's disease brain. There were no significant differences in transglutaminase activity or levels in the cerebellum between control and Alzheimer's disease cases. Because the elevation of transglutaminase in the Alzheimer's disease samples occurred in the prefrontal cortex, where neurofibrillary pathology is usually abundant, and not in the cerebellum, which is usually spared in Alzheimer's disease, it can be suggested that transglutaminase could be a contributing factor in neurofibrillary tangle formation.

Related Edges 2

• a(GO:"neurofibrillary tangle") positiveCorrelation act(p(HGNC:TGM2))
• act(p(HGNC:TGM2)) positiveCorrelation a(GO:"neurofibrillary tangle")

Uberon

prefrontal cortex

Disease Ontology (DO)

Alzheimer's disease

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