act(p(HGNC:AGER)) increases bp(GO:"MAPK cascade")

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PubMed:27288790

Then the stimulation of RAGE is able to activate the mitogen-activated protein kinase signaling cascades which converge in IκB kinase complex to phosphorylate IκB, thereby release and activate NF-κB, thus trigger NF-κB dependent gene transcription including IL-1β and TNF-α, which in turn induce the translocation of NF-κB to the nucleus [50].

Related Edges 6

• bp(GO:"MAPK cascade") increases p(FPLX:IKB, pmod(Ph))
• act(p(FPLX:NFkappaB)) increases p(HGNC:IL1B)
• act(p(FPLX:NFkappaB)) increases p(HGNC:TNF)
• p(FPLX:IKB, pmod(Ph)) increases act(p(FPLX:NFkappaB))
• p(HGNC:IL1B) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))
• p(HGNC:TNF) increases tloc(p(FPLX:NFkappaB), fromLoc(MESH:Cytosol), toLoc(MESH:"Cell Nucleus"))

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