p(HBP:HBP00053, var("p.Lys280del")) decreases tloc(p(HBP:HBP00053, var("p.Lys280del")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))

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PubMed:29024336

This conformational change, but not the aggregation itself, interferes also with tau degradation by e-MI, as we found a significant decrease in the uptake of both mutants by LE (Fig. 6d,e)

Related Edges 1

• p(HBP:HBP00053, var("p.Lys280delinsProPro")) decreases tloc(p(HBP:HBP00053, var("p.Lys280Pro")), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))

MeSH

Multivesicular Bodies

Confidence

High

MeSH

Brain

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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