a(CHEBI:"trichostatin A") increases p(HGNC:MAPT, pmod(Ac))

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PubMed:21427723

Although low-level tau acetylation was observed in untreated HEK-T40 cells, treatment with the pan histone deacetylase (HDAC) inhibitor trichostatin A (TSA), but not the Sir2 class inhibitor nicotinamide, resulted in a dramatic increase in acetylated tau levels.

Related Edges 2

• a(CHEBI:"trichostatin A") directlyDecreases act(p(FPLX:HDAC))
• act(p(FPLX:HDAC)) decreases p(HGNC:MAPT, pmod(Ac))

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