PubMed: 21427723

Title
The acetylation of tau inhibits its function and promotes pathological tau aggregation.
Journal
Nature communications
Volume
2
Issue
None
Pages
252
Date
2011-01-01
Authors
Cohen TJ | Guo JL | Hurtado DE | Kwong LK | Lee VM | Mills IP | Trojanowski JQ

Evidence 103bfa52ea

Although low-level tau acetylation was observed in untreated HEK-T40 cells, treatment with the pan histone deacetylase (HDAC) inhibitor trichostatin A (TSA), but not the Sir2 class inhibitor nicotinamide, resulted in a dramatic increase in acetylated tau levels.

Evidence 276f0ebe3c

Thus, K280 acetylation is a feature found in a variety of human 4R or 3R/4R tauopathies including AD, but not 3R-tauopathies such as PiD.

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