Citation

PubMed: 22142809

Title: Rac1b increases with progressive tau pathology within cholinergic nucleus basalis neurons in Alzheimer's disease.
Journal: The American journal of pathology
Volume: 180
Issue: None
Pages: 526-40
Date: 2012-02-01
Authors: Counts SE | Coutadeur S | Desire L | Getova DP | Geula C | Ginsberg SD | He B | Mufson EJ | Peillon H | Perez SE

Evidence 14e35597d9
JSON

Because we also found Rac1b-positive neurons in the AD cortex, it will be interesting to determine whether these perikarya display a similar gene profile to that found in the NB cholinergic neurons.

a(HBP:"cerebral cortex") positiveCorrelation p(HBP:RAC1b) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: cerebral cortex
Disease Ontology (DO): Alzheimer's disease
MeSH: Alzheimer Disease

p(HBP:RAC1b) positiveCorrelation a(HBP:"cerebral cortex") View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: cerebral cortex
Disease Ontology (DO): Alzheimer's disease
MeSH: Alzheimer Disease

Evidence ce44bdae7d
JSON

CBF tissues harvested from people who died with a clinical diagnosis of no cognitive impairment (NCI), mild cognitive impairment, or AD were immunolabeled for both p75NTR and Rac1b. Rac1b appeared as cytoplasmic diffuse granules, loosely aggregated filaments, or compact spheres in p75NTR-positive NB neurons. Although Rac1b colocalized with tau cytoskeletal markers, the percentage of p75NTR-immunoreactive neurons expressing Rac1b was significantly increased only in AD compared with both mild cognitive impairment and NCI.

p(HBP:RAC1b) association p(HGNC:NGFR) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HGNC:NGFR) association p(HBP:RAC1b) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

Evidence d006f877fa
JSON

Furthermore, single-cell gene expression profiling with custom-designed microarrays showed down-regulation of caveolin 2, GNB4, and lipase A in AD Rac1b-positive/p75NTR-labeled NB neurons compared with Rac1b-negative/p75NTRpositive perikarya in NCI. These proteins are involved in Rac1 pathway/cell cycle progression and lipid metabolism.

p(HBP:RAC1b) negativeCorrelation p(HGNC:CAV2) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HBP:RAC1b) negativeCorrelation p(HGNC:GNB4) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HBP:RAC1b) negativeCorrelation p(HGNC:LIPA) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HGNC:CAV2) negativeCorrelation p(HBP:RAC1b) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HGNC:GNB4) negativeCorrelation p(HBP:RAC1b) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

p(HGNC:LIPA) negativeCorrelation p(HBP:RAC1b) View Subject | View Object

Appears in Networks:

Tau Biochemistry v1.2.5

Annotations

Uberon: basal nucleus of telencephalon
Cell Ontology (CL): cholinergic neuron
Disease Ontology (DO): Alzheimer's disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.