Title

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

Journal

Human molecular genetics

Volume

24

Issue

None

Pages

76-85

Date

2015-01-01

Authors

Basquin M | Blum D | Brouillet E | Buée L | Demeyer D | Francelle L | Gerhardt E | Herrera F | Mendes T | Obriot H | Outeiro TF | Sergeant N

We found strong Tau hyperphosphorylation in brain samples from R6/2 and 140CAG Tg knock-in, associated with a significant reduction in the levels of Tau phosphatases (PP1, PP2A and PP2B), with no apparent involvement of major Tau kinases.

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