1. Catalog
  2. Citations
  3. PubMed:26323690

PubMed: 26323690

Title
TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.
Journal
The Journal of cell biology
Volume
210
Issue
None
Pages
737-51
Date
2015-08-31
Authors
Arimura N | Hoshino M | Ishidate F | Kaibuchi K | Kakeno M | Matsui T | Matsuzawa K | Nishioka T | Shirahige A | Sugiyama I | Taya S | Watanabe T

Evidence 379dc5853e
JSON

Upregulation of SLC5A1 Na-copled Glucose transport

bp(GO:"glucose transmembrane transport") positiveCorrelation act(p(HGNC:SLC5A1)) View Subject | View Object

Appears in Networks:

act(p(HGNC:SLC5A1)) positiveCorrelation bp(GO:"glucose transmembrane transport") View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases act(p(HGNC:SLC5A1)) View Subject | View Object

Appears in Networks:

Evidence b72dd6b20c
JSON

These findings indicate that TTBK2 with EB1/3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at MT plus ends for cell migration.

bp(GO:"microtubule depolymerization") negativeCorrelation p(HGNC:KIF2A, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:KIF2A, pmod(Ph)) negativeCorrelation bp(GO:"microtubule depolymerization") View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) increases p(HGNC:KIF2A, pmod(Ph)) View Subject | View Object

Appears in Networks:

Evidence d57dab868c
JSON

TTBK2 bound EB1 and Cep164 through its SxIP motifs and a proline-rich motif, respectively. Using TTBK2 variants that contained mutations in the SxIP or proline-rich motifs, we obtained evidence that Cep164, but not EB1, is essential for centriolar localization of TTBK2. Therefore, Cep164 binding is essential for the function of TTBK2 in promoting CP110 removal and ciliogenesis. We also provide evidence that TTBK2 has the potential to effectively phosphorylate Cep164 and Cep97 and inhibits the interaction between Cep164 and its binding partner Dishevelled-3 (an important regulator of ciliogenesis) in a kinase activity-dependent manner.

complex(p(HGNC:CEP164), p(HGNC:DVL3)) negativeCorrelation p(HGNC:CEP164, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:CEP164) association p(HGNC:TTBK2) View Subject | View Object

Appears in Networks:

p(HGNC:CEP164) positiveCorrelation act(p(HGNC:TTBK2)) View Subject | View Object

Appears in Networks:

p(HGNC:CEP164, pmod(Ph)) negativeCorrelation complex(p(HGNC:CEP164), p(HGNC:DVL3)) View Subject | View Object

Appears in Networks:

p(HGNC:MAPRE1) association p(HGNC:TTBK2) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) association p(HGNC:CEP164) View Subject | View Object

Appears in Networks:

act(p(HGNC:TTBK2)) positiveCorrelation p(HGNC:CEP164) View Subject | View Object

Appears in Networks:

p(HGNC:TTBK2) association p(HGNC:MAPRE1) View Subject | View Object

Appears in Networks:

act(p(HGNC:TTBK2)) decreases p(HGNC:CCP110) View Subject | View Object

Appears in Networks:

act(p(HGNC:TTBK2)) increases p(HGNC:CEP164, pmod(Ph)) View Subject | View Object

Appears in Networks:

act(p(HGNC:TTBK2)) increases p(HGNC:CEP97, pmod(Ph)) View Subject | View Object

Appears in Networks:

Evidence 268a592eac
JSON

Upregulation of Na+Cl- coupled betaine/GABA transporter BGT1 for organic osmolytes

p(HGNC:TTBK2) increases act(p(HGNC:SLC6A12)) View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.