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PubMed: 16630055

Title
Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.
Journal
The European journal of neuroscience
Volume
23
Issue
None
Pages
2078-86
Date
2006-04-01
Authors
Gong CX | Li X | Lu F | Wang JZ

Evidence 8ad74fb8aa
JSON

We recently discovered that the human brain tau is also modified by O-GlcNAcylation in addition to phosphorylation and that O-GlcNAcylation modulates phosphorylation of tau inversely (Liu et al.,2004a). We found that fasting induced a time-dependent decrease in tau O-GlcNAcylation and concurrent hyperphosphorylation of tau at most of the phosphorylation sites studied.

a(CHEBI:glucose) negativeCorrelation path(MESH:Fasting) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph)) negativeCorrelation p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(HBP:"O-GlcNAcylation")) negativeCorrelation p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Appears in Networks:

path(MESH:Fasting) decreases p(MGI:Mapt, pmod(HBP:"O-GlcNAcylation")) View Subject | View Object

Appears in Networks:

path(MESH:Fasting) increases p(MGI:Mapt, pmod(Ph)) View Subject | View Object

Appears in Networks:

path(MESH:Fasting) negativeCorrelation a(CHEBI:glucose) View Subject | View Object

Appears in Networks:

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