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PubMed: 22798221

Title
Methylglyoxal induces tau hyperphosphorylation via promoting AGEs formation.
Journal
Neuromolecular medicine
Volume
14
Issue
None
Pages
338-48
Date
2012-12-01
Authors
Cheng XS | Du LL | Jiang X | Li XH | Lv BL | Wang JZ | Xie JZ | Zhang JY | Zhou XW

Evidence ffd3ccd9fc
JSON

Taken all together, we think that activation of GSK-3b and p38 should be responsible for MG-induced tau hyperphosphorylation.

a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Gsk3b), ma(kin)) View Subject | View Object

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a(CHEBI:"advanced glycation end-product") increases act(p(MGI:Mapk14), ma(kin)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

act(p(MGI:Gsk3b), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 199)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 198)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

act(p(MGI:Mapk14), ma(kin)) directlyIncreases p(MGI:Mapt, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

Evidence 102c2d2a0d
JSON

Here, we found that MG could induce tau hyperphosphorylation at multiple AD-related sites in neuroblastoma 2a cells under maintaining normal cell viability. MG treatment increased the level of advanced glycation end products (AGEs) and the receptor of AGEs (RAGE).

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 199)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 198)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 202)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 231)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Ser, 396)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(MGI:Mapt, pmod(Ph, Thr, 205)) View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases a(CHEBI:"advanced glycation end-product") View Subject | View Object

Appears in Networks:

a(CHEBI:methylglyoxal) increases p(HGNC:AGER) View Subject | View Object

Appears in Networks:

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