PubMed 29024336

We found that abundance of autophagic vacuoles (autophagosomes + autolysosomes) significantly increased in cells expressing either of the two tau mutants (Fig. 4d,e). This increase was mainly due to higher content of autolysosomes (red puncta) (Fig. 4d,e), in support of increased macroautophagic flux

BEL
p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy)
Hash
9114a1b631
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 29024336

In fact, increased macroautophagy may be responsible for the increase in the degradation of long-lived proteins that we observed for both mutant forms of tau under these conditions (Fig. 3b)

BEL
p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:macroautophagy)
Hash
3421fd0142
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 29024336

Macroautophagy blockage resulted in preferential accumulation of A152T, but not WT and P301L tau (Fig. 2e,f)

BEL
bp(GO:macroautophagy) decreases deg(p(MGI:Mapt, var("p.Pro301Leu")))
Hash
0a0084e313
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 29024336

The most notable difference between the two tau mutants was the inability of P301L to undergo degradation by CMA or by macroautophagy

BEL
bp(GO:macroautophagy) causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu")))
Hash
4506307b89
CellStructure
Multivesicular Bodies
Confidence
Medium
MeSHAnatomy
Brain
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.