PubMed 29024336

The two pseudophosphorylated tau proteins (hTau40 AT8/AT100/PHF-1 and hTau40 4xKXGE) displayed significantly decreased lysosomal uptake when compared to hTau40 WT Tau (Fig. 7a,b)

BEL
p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
Hash
2865719887
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks
BEL
p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases tloc(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
Hash
2865719887
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 29024336

Analysis of e-MI of the pseudophosphorylated forms of tau using LE showed reduced uptake/degradation of hTau40 AT8/AT100/PHF-1 when compared to WT tau (Fig. 7d,e)

BEL
p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)))
Hash
8f2b353ff1
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks
BEL
p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)) decreases deg(p(HBP:HBP00053, pmod(Ph, Ser, 396), pmod(Ph, Ser, 404)))
Hash
8f2b353ff1
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.