PubMed 29024336

Absence of the second N-terminal insert (in 1N3R tau) did not reduce CMA of tau, but instead this isoform displayed faster internalization (lower binding because of more efficient uptake) (Fig. 5b,c)

BEL
a(HBP:HBP00055) increases tloc(p(MGI:Mapt), fromLoc(MESH:"Extracellular Space"), toLoc(GO:lysosome))
Hash
2eaa9692f8
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

PubMed 29024336

Absence of the second N-terminal insert also significantly reduced e-MI of tau (Fig. 5e,f)

BEL
a(HBP:HBP00055) decreases deg(p(MGI:Mapt))
Hash
f38055e37c
CellStructure
Multivesicular Bodies
Confidence
High
MeSHAnatomy
Brain
Networks

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.