Evidences a(HBP:"protein aggregates") to bp(GO:"proteasome-mediated ubiquitin-dependent protein catabolic process")

Recent findings demonstrate that soluble aggregated proteins can inhibit the ubiquitin system (Bence et al., 2001)

Consequently, the formation of aggregates may increase when the UPS fails

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.