PubMed 29024336

Interestingly, although tau-P301L was not degraded in lysosomes, blockage of CMA promoted accumulation of this protein variant, albeit at significantly lower levels than WT and A152T. We propose that overall loss of proteostasis as a consequence of CMA blockage could indirectly affect clearance of tau-P301L through other systems

BEL
bp(GO:"chaperone-mediated autophagy") increases deg(p(MGI:Mapt, var("p.Pro301Leu")))
Hash
72096a8fe1
CellStructure
Lysosomes
Confidence
Medium
MeSHAnatomy
Brain
Networks

PubMed 29024336

The most notable difference between the two tau mutants was the inability of P301L to undergo degradation by CMA or by macroautophagy

BEL
bp(GO:"chaperone-mediated autophagy") causesNoChange deg(p(MGI:Mapt, var("p.Pro301Leu")))
Hash
74fb2defbc
CellStructure
Multivesicular Bodies
Confidence
Medium
MeSHAnatomy
Brain
Networks

PubMed 29024336

Cells expressing tau-P301L displayed significant upregulation of CMA under basal conditions that was no longer observed upon serum removal (Fig. 3c–e)

BEL
p(MGI:Mapt, var("p.Pro301Leu")) increases bp(GO:"chaperone-mediated autophagy")
Hash
43cffb8b95
CellStructure
Intracellular Space
Confidence
High
MeSHAnatomy
Brain
Networks

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.