Table of Contents

Contradictory Triplets 6

Analysis of triple stability comes from a deep graph theoretic background. It identifies triangles within the graph that have logically inconsistent relations.

Separately Unstable Triplet
When both A positiveCorrelation B, B negativeCorrelation C, but C positiveCorrelation A.
Mutually Unstable Triplets
When both A negativeCorrelation B, B negativeCorrelation C, and C negativeCorrelation A.
Jens Contradictory Triplet
When A increases B, A decreases C, and C positiveCorrelation A.
Increase Mismatch Triplet
When A increases B, A increases C, and C negativeCorrelation A.
Decrease Mismatch Triplet
When A decreases B, A decreases C, and C negativeCorrelation A.
Type Node A Node B Node C
Jens p(HGNC:IL18) p(HGNC:PYCARD) path(MESH:"Alzheimer Disease")
Jens complex(GO:"inflammasome complex") p(HGNC:CASP1) p(HGNC:IL18)
Jens complex(GO:"inflammasome complex") p(HGNC:CASP1) p(HGNC:IL1B)
Jens bp(GO:aging) p(HGNC:IL1B) path(MESH:"Alzheimer Disease")
Jens bp(GO:aging) p(HGNC:IL18) path(MESH:"Alzheimer Disease")
Jens p(HGNC:IL1B) p(HGNC:PYCARD) path(MESH:"Alzheimer Disease")

Causal Pathologies 6

Pathologies are more dogmatically the result of molecular and physical processes, and do not necessarily make sense as the subject of causal statements.

Source Relation Target
path(MESH:"Spinal Cord Injuries") increases a(CHEBI:ATP)
path(MESH:"Spinal Cord Injuries") increases complex(GO:"NLRP1 inflammasome complex")
path(MESH:"Spinal Cord Injuries") increases p(HGNC:IL18)
path(MESH:"Spinal Cord Injuries") increases p(HGNC:IL1B)
path(MESH:"Trauma, Nervous System") increases complex(GO:"inflammasome complex")
path(MESH:Stroke) increases complex(GO:"inflammasome complex")

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.